Abel, J.J. 80
abolitionists 205
absorption 184
accursed fields 13
acetylcholine 169
actinomycin D. See cancer, anticancer, drugs
actively acquired tolerance 93
adenovirus
vaccine. See vaccination
adrenocorticotrophic hormone 156
Advertising Standards Authority 196
Afghanistan 10
AIDS 53
Alderslade, R. 47
Algeria 21
alizarin dye 192
Allen, F. 148
allograft. See transplant
American civil war 32
American Physiological Society 145
American Society of Teratology 196
aminopterin. See cancer, anticancer, drugs
amylin 153
anaemia 84-85, 87, 130, 136, 206
anaesthetised
cat 169
dogs 82
anastomosis 88
angiocardiography 119
angiotensin
converting enzyme (ACE) 173
receptor antagonists 174
animal
experimentation 61, 143, 163, 171, 177, 178. See also vivisection
research xiv, xviii, xix, xx, 14, 61, 85, 127, 181, 204
rights. See also antivivisection
organisations xix-xx, 14, 54, 61, 143
studies 24, 32, 80, 81, 90, 91, 181, 185
vaccine. See vaccination
antibiotics 3, 36, 47, 52, 57, 58, 84, 178, 180, 206
antibiotic-induced colitis. See colon
penicillin. See penicillin
antibodies 24-26, 91, 96, 98, 100, 133, 134, 138, 206
anticoagulants 80-82, 82, 106, 119, 124-125, 134-136, 138, 139
anticoagulant therapy 119, 122, 124
antigens 134
antigenic cross reacting materials 74
transplantation 98
antilymphocyte serum (ALS) 97-98, 153
antineoplastic drugs 202
antiseptic powder 17
antitoxin
Anti-Vaccination League. See vaccination
antivivisection 47, 151-152. See also animal rights; vivisection
movement 69, 71, 168, 174, 178
National Anti-Vivisection Society xvii, 172
propaganda 144
Arbois 20
Argentina 13
arteries. See blood, vessels
asses 70
Association of American Physicians 148
Association of the British Pharmaceutical Industry 193
atheromatous changes 115
Australia 188
Austria 7
autograft. See transplant
autonomic reflexes 171
Avery, G. xviii
bacteriological diagnosis 70
Baginskys clinic 69
Bali 10
Bangladesh 18
Banting, F. 145
Bavaria 6
Bavarian Institution for Crippled Children 187
Bazy, L. 33
Beddow Bayly, M. 69
benzalkonium chloride 24
Berger, F.M. 185
Bergey, D.H. 34
Bernard, C. 170
Best, C. 145
beta blockers 172-173. See hypertension
bethanidine 171
bioprosthesis. See heart, valves, prosthesis
Birmingham 72
Björk-Shiley valve. See heart
Björk, V. 121. See also Björk-Shiley valve
Blakemore, C. xviii
blood xx, 4, 13, 14, 26, 35, 42, 60, 72, 80-86, 88, 89, 103-109, 115-118, 155, 162, 184, 185
bleeding disorder 124
time 135
anti-Rh antibodies 138
haemoglobin
haemoglobinaemia 133
pressure 87, 88, 167-176. See also hypertension
reactions 134
services 137
vessels 88, 90, 100, 118, 123, 134, 144, 206
arteries 88, 103, 105, 128-129, 132-134, 155, 173. See also lungs, pulmonary artery
veins 31, 80, 88, 125, 128-129, 132-134. See also lungs, pulmonary vein
Boer War 32
bone marrow 206
Bordetella pertussis 42
Borrel, A. 31
Boston Public Health Service Hospital 94
Bothrops jararaca 173
Boyle, R. 128
bradykinin 173
potentiating factor 173
Brazil 9
Breslau 145
Bretonneau, P.-F. 65
Brigham Hospital 90
Britain. See Great Britain
British Medical Journal 150
British Thoracic Society 53
bronchi 42
Bruschettini, A. 30
Burkitt, D.P. 205
Burkitt’s lymphoma 199
Burma 10
Burroughs Wellcome Research 96
Cabasso, V.J. 24
caged-ball valve. See heart
calcitonin 156
Calne, R. 96
calves. See cows
Cambridge University 150
anticancer
6-mercaptopurine 96
actinomycin D 203
aminopterin 203
vincristine 203
chemotherapy 58, 202-204, 205-206
carcinogenicity 194
metastases 206
Cannon, J.A. 93
cardiac valves. See heart
cardioplegia. See heart
cardiopulmonary bypass. See heart
Carnot, P. 206
Carpentier, A. 124
cats 66, 88, 100, 104, 105, 159, 161, 171
rabid 20
cattle 13, 14, 19, 93, 117, 124, 143
twins 93
cauterization 24
Cawley, T. 144
celloidin 80
tubing 81
Cesarean section 192
chemical messengers 155
Chemie Grünenthal 183
chemotherapy. See cancer, anticancer therapies
cholera. See cholera
China 18
Chinese hamster 48
chloroform 164
chlorothiazide 171
chordae tendineae 117
Christie, G. 191
chronic
myelogenous leukaemia 201
renal failure. See kidney, renal failure
Ciba Company 171
cisplatin 205
citrate 135
Clinical Society 70
Clostridium
difficile 180
perfringens 178
tetani 30
coagulation. See blood
Cobbett, L. 70
cold-blooded animals. See blood
Collip, J. 146
collodion 79
colloids 79
colon 180
enterocolitis 179
Colton, Q. 163
Columbia University 134
Committee on the Safety of Drugs 183, 194
Contergan 186
Cornelius, C.E. 156
Corrigan, D.J. 116
cortisone 97
Corynebacterium diphtheriae. See diphtheria
cowpox 5
Crimean war 32
crystalloids 79
cyclophosphamide 203
cytotoxic drugs 204
Dacron felt 117
Dale, H. 150
Dameshek, W. 96
Darwin, E. 130
Davila, J. 121
Davis, L.E. 159
Davy, H. 161
decamethonium 169
deer 127
de la Condamine, C.-M. 4
Denver 9
Department of Health 46
Descombey, P. 34
De Somer, P. 179
juvenile onset 143
late onset 152
dicoumarol 125
bacillus diphtheriae 66
Corynebacterium diphtheriae 66
/tetanus/pertussis 43
vaccine. See vaccination
disc valves. See heart
Distaval 188
Distillers Company 184
dogs 21, 66, 80, 81, 82, 83, 88, 96, 98, 100, 104, 105, 109, 117, 123, 127, 128, 135, 143, 146, 153, 171
depancreatized 145
hounds 18
irradiated 95
rabid 20
Dollery, C. 167
Domagk, G.J.P. 177
Donnelly, E.J. 159
Dunedin 170
Dunlop, D. 194
Duran, C. 123
Düsseldorf 186
earthworms 13
Edinburgh University 163
Elberfeld 177
elective cardiac arrest. See heart, open heart surgery
electrodialysis 124
embolism 104
Emmerez, P. 129
encephalopathy 45
Encyclopaedia Britannica 157
Enders, J.F. 61
endothelial cell 89
England 6, 7, 8, 17, 18, 41, 42, 43, 44, 62, 200, 201. See also Great Britain; United Kingdom
enterocolitis. See colon
epidemiology 205
epoprostenol 82
Epstein-Barr virus 199
vaccine. See vaccination
ether 161-164. See also anaesthesia
Ethiopia 9
ethyl alcohol 24
ethylene dibromide 163
Etris, S. 34
Expert Committee on Drug Toxicity 194
Expert Committee on Rabies 25
extracorporeal circuit 80, 104-106. See also heart, open heart surgery
Fermi, E. 21
Ferreira, S. 173
ferrets 205
fetus
fetal abnormalities 158, 187-198
fever hospitals 65
flexible cusp valve. See heart
Florence, A. L. 186
Florey, H. 178
Flourens, M.J.P. 163
fluoroscopy 119
Folkman, J. 206
Food and Drugs Administration 183
Forschbach, J. 145
foxes 26
rabid 19
Fox, R.R. 192
Franco-Prussian war 32
French Parliament 130
Frenkel, H. 186
fumagillin 206
ganglion 169
Ganter, G. 83
gardening 37
gastritis 87
geese 130
gene therapy 207
Germany 187
Gibbon, J. 104
Gilman, A. 202
Glenny, A.T. 70
glutaraldehyde 124
Graham, T. 79
Gram-positive microorganisms 179
granisetron 205. See also cancer therapies
gravitator 132
Great Britain 18, 46, 69, 73, 162. See also England; United Kingdom; Wales
Greek, C.R. 196
Greek, J.S. 196
Greenwich Hospital 71
Grippex 186
Grist, G. 46
guanethidine 171
guinea pigs 12, 13-14, 24-25, 29, 31, 34, 66, 67, 70, 81, 83, 97, 124, 135, 138, 161, 177, 178-179, 180-181, 184, 189
germ-free 179
neonatal 181
Gunning, A. 123
Haas, G. 81
Habel, K. 25
Habig, W. 35
haemodialysis. See dialysis
haemoglobinaemia. See blood, haemoglobin
Haemophilus influenzae 51
haemorrhagic fever 53
Hamburg 188
Hamre, D. 178
kidney cells 25
hantaviruses 53
Health Committee of the League of Nations 71
Hearse, D. 109
heart 87, 95, 103-104, 108, 118, 120, 127, 138, 155-156, 170
attack 149
cardioplegia
cardioplegic solution 107, 109-114
cold 112
coronary heart disease 174
heart-lung machine 107
cardiopulmonary bypass 103-114
elective cardiac arrest 104, 108-109, 109
valves
allograft 123
Björk-Shiley valve 121
flexible cusp valve 118
tilting disc valve 121
tricuspid 116
left ventricular hypertrophy 116
ventricular fibrillation 109
ventricular tachycardia 155
hens 12
heparinised blood 136
hepatitis B 207
vaccine. See vaccination
hexamethonium 170
Hib infection 52
Hickman, H. 162
Hippocrates 29
histamine sensitisation test 48
Hitchings, G. 96
Hodgkin’s disease 199, 200, 202
homograft. See transplant
Hopkins, B.E. 70
horses 5, 25, 31, 66, 67, 70, 98, 100
plasma 67
Hospital for Sick Children in Paris 68
human diploid cell line (HDC) 26
human diploid cell vaccine (HDCV) 26. See vaccination
Hungary 21
hydralazine 171
hydrophobia 18
antihypertensive
ACE Inhibitors. See angiotensin, converting enzyme (ACE)
beta blockers. See beta blockers
hysteria 17
iatrogenic condition 180
immunisation 34, 43, 63, 71. See also vaccination
immune serum 24
immunological barrier 94
drugs 96
impellor 132
vaccine. See vaccination
insecticides 53
insulin xv, xx, 143-154, 156, 158
intense radiation 95
intubation 66
Ireland 73
iron lungs 57
Jackson, C. 163
Japan 21
Java 10
Jenner, E. 5
Judaeus, I. 4
Jung, H. 184
Kansas 9
Kaufman, S. xiv
Kefauver-Harris Amendment 195
Keller, K.A. 193
Kendrick, F.J. 192
kidney 25, 79-85, 81, 87-100, 106, 144, 185, 200, 207
dialysis. See dialysis
polycystic disease 87
renal failure
acute 79
transplant. See transplant
Kiel 188
King, C.T.G. 192
Klebs, E. 66
Koch, R. 13
Kolff, W. 81
Koprowski, H. 25
Kosenow, W. 187
Krefeld 188
Lacassagne, A. 204
lambs. See sheep
Lam, C. 123
Lancet, The 189
Landois, L. 133
Landsteiner, K. 52, 60, 133, 138, 139
Larrey, D.J. 32
laughing gas 163. See nitrous oxide
L1210 mouse leukaemia model 204
leukocytosis-promoting activity 48
Lillie, F. 93
lockjaw. See tetanus
Loeb, L. 93
Loeffler, F. 66
Long, A. 35
Longmire, W.P. 93
Ludlow 162
lungs
pulmonary
embolism 134
vein 115
Lyon 19
Macleod, J. 146
Madras 23
malaria 53
antimalarial drugs 53
malignant sore throat 65
Mary Imogene Bassett Hospital 95
Massachusetts General Hospital 105
Mayo Clinic 118
Foundation 90
McBride, W.G. 188
McLean, J. 81
McNeil, J.R. 158
measels
vaccine. See vaccination
Medawar, P. 91
Medical Advisory Committees 193
Medical Officers of Health 71
Medical Research Council 42
Medizinische Welt 186
Meister, J. 22
Melrose, D.G. 109
vaccine. See vaccination
meningococcal
vaccine. See vaccination
meprobamate 185
metaperiodate oxidation 124
metastases. See cancer
Metchnikoff, É. 97
methotrexate 204
Metropolitan Life Insurance 143
Metropolitan Streets Act 19
mice 5, 14, 24-26, 29-31, 34, 42-43, 48, 53, 60-61, 81, 91, 93, 94, 95, 97, 98, 100, 153, 171, 172, 177-178, 183-185, 189, 192, 194, 203-204, 206
B16 melanotic melanoma 203
Lewis lung carcinoma 203
mouse protection test 42, 43, 177
non-obese diabetic [NOD] mouse 153
nude 153
P388 mouse leukaemia 203
microemboli 106
Miller, D. 47
monkeys 33, 53, 59-61, 70, 83, 98, 100, 183, 185
aotus monkeys 53
red cells 138
rhesus monkeys. See rhesus factor
monoclonal antibodies 206
Moore, F. 98
Morocco 21
morphine 159
Morton, W.T.G. 163
Moscow 137
mosquito 53. See also malaria
mules 5
mumps
vaccine. See vaccination
Mylar 118
mysid 127
National Anti-Vivisection Society. See antivivisection, organisations
National Institute of Medical Research 151
neoplastic disease 199
Nepal 10
nephrectomy 85
neurological illness 45
neuromuscular blocking drugs 36
newt 193
Nicolaier, Arthur 29
nitric oxide 174
nitrogen mustards 202-203. See also cancer
nitrous oxide 161
North America 9, 57, 149. See also USA
North Dakota 125
ondansetron 205
open heart surgery. See heart
Owen, R. 93
ox 104
Oxford 178
Oxford University 92
ox serum ultrafiltrate 61
oxygenator 103
oxytocin 156
cattle 143
dogs 144
extracts of 145
pancreatic islets 152
transplant. See transplant
papilloedema 167
papillomavirus 207
vaccine. See vaccination
paraesthesia 186
paralysis 20, 34, 58-61, 65, 87
infantile 58
parathyroid glands 156
Paris 130
paroxysmal cough 42
Pasteur Institute 23
Pasteur, Louis 3, 11-15, 20-24, 26, 66
Patarroyo, M.E. 53
Penicillium 177
Pepys, S. 128
pericarditis 87
peritoneal dialysis. See dialysis
peritonitis 84
vaccine. See vaccination
Pfeiffer, R.F.J. 187
pharmacokinetic data 82
Philippines 18
Philips, F. 202
phocomelia 187
physicochemical methods 152
Physiology Department at Toronto 146
pigs 98, 104, 123, 138, 143, 153, 155-156
aortic valves 123. See also heart
transgenic 98
pituitary 156
plasmaphaeresis 26
platelet aggregation 82
Plegisol 112
Plymouth 19
pneumococci 53
pneumonia 41, 46, 58, 95, 96, 193
lobar pneumonia 58
pneumococcal
vaccine. See vaccination
poliovirus 60
vaccine. See vaccination
polycystic kidney disease. See kidney
polymethylene-bisquaternary ammonium salts 169
polyneuritis 186
post-exposure prophylaxis 22
post-partum haemorrhage 131
Pottevin, H. 23
Prichard, B. 172
pronethalol 172
prosthesis 103. See also heart, valves
protamine 106
prothrombin time 125
puerperal sepsis 58
rabbits 5, 12, 20, 25, 29, 30, 42, 53, 66, 68, 70, 80, 81, 82, 83, 85, 92, 95, 96, 98, 100, 104, 109, 124, 125, 134, 136, 153, 163, 170, 183, 206
antigen 26
anti-rabies antibodies 25
immune globulin of human origin (RIGH) 26
vaccine. See also vaccination
raccoons 26
Ramon, G. 70
rats 82, 85, 104, 124, 155, 171, 173, 183, 185, 191
cotton rat 60
heart 109
pregnant 191
spontaneously hypertensive rats (SHR) 173
tissue 36
recombinant techniques 152
Reid, W. 163
rejection 24, 89-100, 123, 153. See also transplant
antirejection therapy 98
renal failure. See kidney, renal failure
Research Defence Society (RDS) xix, xx
reserpine 171
resorption 191
rhesus factor 138
rhesus monkeys 33
rhesus red cells 138
Richards, I.D.G. 158
Richardson, B. 79
Robinson, K. 193
Rockefeller Institute 134
Rosa, M. 130
Ross, E. 47
Rowan, A. 152
Royal College of General Practitioners 47
Royal College of Surgeons 173
Royal Society 162
rubella
vaccine. See vaccination
Runner, M. 193
Russia 74
Sartwell, P. 35
Scandinavia 58
Scarpa, A. 130
Schardein, J.L. 193
Schering Company 145
Schick test 71
Schottstaedt, M. 167
Schumacher, H. 192
Schwartz, R. 96
scrub typhus
vaccine. See vaccination
“second set phenomenon” 92
S(-)-enantiomers 192
septal defect 106
serotherapy 68
plasma 138
Sherrington, C.S. 33
Shiley, D. 121. See also Björk-Shiley valve
silage 125
Silastic ball 119
Simon, J. 7
Simpson, J.Y. 163
Singer, P. xviii
sipuleucel-T. See vaccination
skeletal malformations 187
slow-release depot preparations 151
vaccine. See vaccination
Snell, G.D. 98
Sokolow, M. 167
Somalia 11
Somers, G. 190
SPf66. See vaccination
Sri Lanka 18
Staphylococcus aureus 177
Starling, E.H. 83
Starr, A. 119
stenosis 115
Stetson, R. 138
Stewart, G. 47
St Marys Hospital in London 192
Stop Huntingdon Animal Cruelty (SHAC) xviii
St Thomas’s Hospital 109
Sudan 9
Sulawesi 10
surgery 31, 87-102, 161-162, 164, 169. See also transplant
open heart. See heart
sweet clover 125
sympathectomy 169
synaptobrevin 36
tacrolimus (FK 506) 98
tamoxifen 204
Tankersley, D. 35
Tanzania 53
Teflon 117
Temple, N. 205
Temple University 121
teratogenic effects 183
tetanus 5, 29-37, 41, 43, 46, 53
anti-tetanus prophylaxis 33
neonatal 35
vaccine. See vaccination
Thailand 18
thrombocytopenia 82
thromboembolism 125
thyrotropin 156
tilting disc valve. See heart, valves
tissue typing 98
toad 155
Tolypocladium inflatum 97
toxin/antitoxin mixtures 70
trachea 42
tracheotomy 69
transfusion. See blood
transplant 85, 87-102, 123. See also surgery
cross grafting 94
islet cells 153
tricuspid valve. See heart
vaccine. See vaccination
Tufts University 96
typhoid 54
United Hospitals of St Thomas and Guy 131
United Kingdom 183, 186, 194, 196. See also England; Great Britain; Wales
University of Minnesota 117
University of Toronto 143
USA 21, 46, 52, 61, 163, 187, 200. See also North America
base hospital 136
troops 35
vaccination 51-54, 207. See also immunisation
adenovirus 54
Anti-Vaccination League 71, 72
Epstein-Barr virus 199
Hib meningitis 54
human diploid cell (HDCv) 25
influenza 54
measels 54
meningococcal meningitis 54
mumps 54
papillomavirus 207
plague 54
pneumococcal pneumonia 54
PRP 52
rubella 54
scrub typhus 54
sipuleucel-T 207
SPf66 53
typhoid 54
yellow fever 54
vaccinia virus 26
Vane, J. 173
vasopressin 156
veins. See blood
Vermont 58
vesicular eruption 4. See also smallpox
veterinary research 181
vincristine. See cancer, anticancer, drugs
virus fixe 21
vividiffusion 80
vivisection 196. See also antivivisection
voluntary muscle relaxants 169
von Behring, E. 31, 66, 67, 68, 70
von Mering, J. 144
Voss, R. 186
Wada, J. 121
Wakely, T. 164
Wales 7, 8, 41, 43, 44, 62, 200, 201. See also Great Britain; United Kingdom
Warfarin 124
Wegner, G. 82
Weicker, H. 188
Weidenbach, A. 187
Wells, H. 163
White, P.D. 117
whooping cough. See pertussis
Wiedeman, M. 188
Wilkins, R. 168
Williamson, C. 90
Williams, R.T. 192
wolves
rabid 19
Womens Hospital, Sydney 188
Woodruff, H. 97
World Health Assembly 9
World Health Organization (WHO) 9-12, 34, 36, 57, 63, 73
World War I 32, 35, 81, 89, 136
World War II 35, 42, 57, 91, 137, 202
xenografts. See transplant
xenotransplants. See xenograft
yellow fever
vaccine. See vaccination
Yersin, A. 66
Yugoslavia 21
zinc endopeptidase enzyme 36
Zinsser, H. 7
Zülzer, G. 145